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Kenneth Omeruo, Tyronne Ebuehi, Henry Onyekuru, Wilfred Ndidi and Ahmed Musa has been ruled out of the friendly match billed to hold on Tuesday against Ukraine at the Dnipro Arena over an injury sustained.
Musa is the latest player to be ruled out after picking an injury while playing for his club in Saudi Arabia, Al Nassr.
He has made only two appearances this season for his club.
Henry Onyekuru has a delay with his work permit in his new club which caused him to be ruled out of the game.
Italy based, Udinese defender William Ekong will replace captain Musa in leading the Super Eagles as they fly out against Ukrainian national team.
In order to strengthen the team, the Super Eagles coach, Gernot Rohr has made four new inclusion as a replacement.
Emmanuel Dennis, Josh Maja, Anderson Esiti and Bryan Idowu were the new players added to the team.